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SYRE · Spyre Therapeutics, Inc.
> Ask across nine datasets ⌘K
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TEAM-0.32% 13F +439META+3.01% 13F +2,694RCG-2.04% CLUSTERUTHR-4.03% 13F +425CRWV+4.49% 13F +693CRM+2.92% 13F +1,018CVNA-0.98% 13F +794TPL-0.71% 13F +444NET+4.32% 13F +710MSTR+17.56% 13F +526DELL+4.91% 13F +1,203CRWD+5.68% 13F +1,382ANET+1.22% 13F +1,323COIN+10.14% 13F +475TEAM-0.32% 13F +439META+3.01% 13F +2,694RCG-2.04% CLUSTERUTHR-4.03% 13F +425CRWV+4.49% 13F +693CRM+2.92% 13F +1,018CVNA-0.98% 13F +794TPL-0.71% 13F +444NET+4.32% 13F +710MSTR+17.56% 13F +526DELL+4.91% 13F +1,203CRWD+5.68% 13F +1,382ANET+1.22% 13F +1,323COIN+10.14% 13F +475
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SYRE

Spyre Therapeutics, Inc.
PHARMA & BIOTECH · PHARMACEUTICAL PREPARATIONS · CIK 0001636282
FORM 144 · 8☆ WATCH
INSIDER NET · 180D
-$433.5M
open-market buys minus sells, Form 4 codes P and S
INSIDER BUYERS · 180D
0
CONGRESS BUYERS · 1Y
0
FUNDS ADDED · QTR
192
13F, latest reported quarter
REVENUE GROWTH
-
XBRL, annual
NET MARGIN
-
CONVERSIONS · 180D
15
codes C/M, not in net · $4.2M priced
SEVEN FACTS, RANKED AGAINST THE SECTOR · RANK IS NOT A FORECAST
INSIDERS
net -$433.5M over 180 days
-$416.3M over 90 days
the lowest in Pharma & Biotech
CONGRESS
no member of Congress has reported trading it
FUNDS
192 funds added or opened last quarter
more than 86% of Pharma & Biotech
REVENUE
no revenue reported in any filing
MARGIN
no margin: this company reports no revenue to divide by
BUYBACKS
no share repurchases reported
SHORT
no short interest reported
THE SITUATION · EVERY LINE IS ONE RULE OVER ONE DATASET
Insiders are net sellers: -$433.5M across 7 people in 180 days.
192 funds added or opened positions in the latest 13F quarter, of 270 holders.
The year, with the filings on it
Total return indexed to 100 over the last 12 months · every marker is a federal filing, placed at its date — hover any marker for the detail
TOTAL 12M RETURN +423.5%
+423.5%12M
-11%+178%+366%+555%2025-092025-102025-122026-032026-052026-072026-09 2026-06-23 · Fairmount Funds Management LLC sold $399.7M2026-05-08 · HENDERSON MICHAEL THOMAS sold $2.5M2026-06-22 · HENDERSON MICHAEL THOMAS sold $2.0M2026-05-08 · HENDERSON MICHAEL THOMAS sold $1.9M2026-09-02 · Burrows Scott L sold $1.6M2026-05-01 · Sloan Sheldon sold $1.5M2026-05-08 · HENDERSON MICHAEL THOMAS sold $1.5M2026-09-01 · King-Jones Heidy sold $1.4M2026-05-01 · Sloan Sheldon sold $1.4M2026-08-07 · Albers Jeffrey W. sold $1.0M2026-05-01 · Sloan Sheldon sold $932.0K2026-05-01 · Burrows Scott L sold $892.1K2026-07-01 · Turtle Cameron sold $889.8K2026-06-25 · Burrows Scott L sold $871.4K2026-08-07 · Albers Jeffrey W. sold $835.0K2026-05-01 · Sloan Sheldon sold $763.8K2026-09-01 · Turtle Cameron sold $732.1K2026-08-03 · Turtle Cameron sold $680.6K2025-11-03 · Turtle Cameron sold $651.2K2026-05-01 · Sloan Sheldon sold $628.1K2026-06-03 · Sloan Sheldon sold $625.0K2026-04-01 · Turtle Cameron sold $607.3K2026-06-01 · Turtle Cameron sold $574.5K2026-07-01 · Sloan Sheldon sold $568.9K2026-09-01 · King-Jones Heidy sold $547.2K2026-08-03 · Turtle Cameron sold $540.6K2026-08-07 · Albers Jeffrey W. sold $522.4K2026-07-01 · Burrows Scott L sold $505.6K2026-08-03 · Burrows Scott L sold $485.6K2026-02-02 · Turtle Cameron sold $461.6K2026-06-25 · Burrows Scott L sold $435.6K2026-09-01 · King-Jones Heidy sold $418.6K2025-11-03 · Turtle Cameron sold $398.6K2026-04-01 · Sloan Sheldon sold $397.9K2026-01-02 · Turtle Cameron sold $387.2K2026-03-02 · Turtle Cameron sold $386.7K2026-09-01 · Burrows Scott L sold $381.9K2026-05-01 · Sloan Sheldon sold $377.4K2026-07-01 · Turtle Cameron sold $373.1K2026-05-01 · Turtle Cameron sold $368.6K2026-09-01 · Turtle Cameron sold $325.8K2025-12-01 · Turtle Cameron sold $315.9K2026-09-01 · HEIDY KING-JONES filed to sell $4.2M2026-08-07 · SESSIONS, LLC filed to sell $1.9M2026-08-07 · JEFFREY ALBERS filed to sell $517.1K2026-08-03 · SCOTT BURROWS filed to sell $2.9M2026-07-01 · CAMERON TURTLE filed to sell $4.0M2026-06-25 · SCOTT BURROWS filed to sell $1.3M2026-06-23 · Fairmount Healthcare Fund II L.P. filed to sell $399.7M2026-06-22 · MICHAEL HENDERSON filed to sell $1.8M
INSIDER SELLFORM 144
INDEXED RETURN, DIVIDEND-ADJUSTED — NOT A PRICE CHART · LARGE TRADES DRAWN FIRST WHEN A NAME FILES HEAVILY
Live price
Daily candles from TradingView, on their licence — no filings are marked on this one
WHY THIS NAME IS ON THE DESK
Insiders have filed to sell — before selling.
The record shows a net $433.5M sold by insiders over 180 days, 192 funds added last quarter, $416.2M in planned Form 144 sales. Every figure is a federal filing, dated the day it became public.
Backtest this pattern Open the screener
Same sector, ranked by filing activity
Sector from the SEC's own SIC classification
UTHRCPIXMRNAREGNLLYALNYELFCITRMDGLDNAVRTXNUVL
Insider transactions
Form 4 purchases and sales (codes P and S) — grants, option exercises and preferred conversions excluded

Over the last 180 days, Spyre Therapeutics, Inc. insiders sold a net $433.5M of stock across 83 Form 4 purchases and sales, with 0 insider(s) buying. Source: SEC Form 4 filings, as of 2026-09-05.

INSIDER
FILED
SHARES
VALUE
Burrows Scott L
Chief Financial Officer
SELL
2026-09-02
18,232.0
$1.6M
King-Jones Heidy
See Remarks
SELL
2026-09-02
400.0
$36.0K
Burrows Scott L
Chief Financial Officer
SELL
2026-09-01
900.0
$77.6K
Burrows Scott L
Chief Financial Officer
SELL
2026-09-01
4,384.0
$381.9K
Burrows Scott L
Chief Financial Officer
SELL
2026-09-01
2,016.0
$177.5K
83 TRANSACTIONS ON RECORD

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Institutional holders
13F · holdings as of the latest quarter funds have reported
FMR LLC
13,026,187.0 sh
$1.2B
BlackRock, Inc.
6,506,605.0 sh
$577.7M
PERCEPTIVE ADVISORS LLC
4,319,496.0 sh
$383.5M
RTW INVESTMENTS, LP
4,251,996.0 sh
$377.5M
Paradigm Biocapital Advisors LP
3,840,778.0 sh
$341.0M
SCHEDULE 13D/G
No 5%+ ownership filings
Nobody has crossed 5% with a filing obligation. Absence is a fact here, not missing data.
Planned sales · Form 144
Filed before the sale — intent, not a trade
HEIDY KING-JONES
FILED 2026-09-01
$4.2M
SESSIONS, LLC
FILED 2026-08-07
$1.9M
JEFFREY ALBERS
FILED 2026-08-07
$517.1K
SCOTT BURROWS
FILED 2026-08-03
$2.9M
CAMERON TURTLE
FILED 2026-07-01
$4.0M
Fund concentration
N-PORT · funds ranked by how much of THEMSELVES they put in this stock — the conviction number 13F cannot show
F/m Emerald Life Sciences Innovation ETF
$4.2M POSITION · AS OF 2026-02-28
4.4%
Fidelity Advisor Biotechnology Fund
$63.4M POSITION · AS OF 2026-04-30
3.3%
ALGER HEALTH SCIENCES FUND
$1.4M POSITION · AS OF 2026-04-30
2.3%
ALPS Medical Breakthroughs ETF
$3.0M POSITION · AS OF 2026-02-28
2.2%
Virtus Biotech Clinical Trials Etf
$611.1K POSITION · AS OF 2026-04-30
1.6%
Franklin Biotechnology Discovery Fund
$16.4M POSITION · AS OF 2026-04-30
1.6%
SEC N-PORT, MONTHLY WITH A ~60-DAY PUBLIC LAG · FUNDS ≥ $10M · % = SHARE OF THE FUND'S OWN BOOK
Clinical pipeline
ClinicalTrials.gov · 8 registered trials, 5 still enrolling or running — a status change here is dated weeks before the press release
4
Phase 1
1 ACTIVE
4
Phase 2
4 ACTIVE
TRIALS MATCHED TO THIS TICKER BY SPONSOR NAME · STUDIES RUN UNDER A SUBSIDIARY'S OWN NAME ARE NOT INCLUDED
Fundamentals
Annual figures from XBRL filings · pick a past date to see them exactly as the market knew them then — restatements and all
2025-122024-122023-122022-12
REVENUE$0$0$886.0K$2.3M
OPERATING INCOME$-209.6M$-208.6M$-242.3M$-84.8M
NET INCOME$-155.2M$-208.0M$-338.8M$-83.8M
EPS (DILUTED)——13.76-24.86
OPERATING CASH FLOW$-169.3M$-157.4M$-99.9M$-80.1M
CASH$85.7M$89.4M$188.9M$34.9M
SEC XBRL · FISCAL-YEAR PERIODS · AS KNOWN ON 2026-09-05 · NOBODY ELSE SHOWS FUNDAMENTALS AS OF A PAST DATE
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Public filings, honestly analyzed. Official US government sources in one desk — every figure carries the date it was filed, and the methodology is published, backtest included.

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© 2026 WAVEMAN · SOURCE: SEC EDGAR & OFFICIAL GOVERNMENT DATA · NOT INVESTMENT ADVICE · CHART BY TRADINGVIEW · UPDATED 2026-09-05 ALL SYSTEMS LIVE FOR MACHINES →