Perceptive Advisors LLC 13F holdings
Perceptive Advisors LLC reported 99 positions with a total reported value of $6.4B as of 2026-06-30, in its 13F for Q2 2026, filed 2026-08-14. Top holdings by reported value: PRAX PRAXIS PRECISION MEDICINES I (10.6%), SYRE SPYRE THERAPEUTICS INC (6.0%), CELC CELCUITY INC (5.2%), ASND ASCENDIS PHARMA A/S (4.8%), RYTM RHYTHM PHARMACEUTICALS INC (4.5%). Against 2026-03-31 it opened 21 new positions and exited 11. Next 13F due by 2026-11-14, the legal deadline 45 days after the quarter ending 2026-09-30.
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Top holdings
25 largest of 99 positions · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| PRAX PRAXIS PRECISION MEDICINES I | 2,035,986 | $681.6M | 10.6% |
| SYRE SPYRE THERAPEUTICS INC | 4,319,496 | $383.5M | 6.0% |
| CELC CELCUITY INC | 3,197,200 | $334.5M | 5.2% |
| ASND ASCENDIS PHARMA A/S | 1,163,721 | $310.4M | 4.8% |
| RYTM RHYTHM PHARMACEUTICALS INC | 2,586,295 | $287.2M | 4.5% |
| ROIV ROIVANT SCIENCES LTD | 8,085,461 | $286.1M | 4.5% |
| RLAY RELAY THERAPEUTICS INC | 14,106,187 | $263.9M | 4.1% |
| TVTX TRAVERE THERAPEUTICS INC | 3,752,574 | $213.2M | 3.3% |
| KARD KARDIGAN INC | 8,200,662 | $195.6M | 3.0% |
| NUVL NUVALENT INC | 1,580,505 | $195.2M | 3.0% |
| EWTX EDGEWISE THERAPEUTICS INC | 4,373,974 | $177.7M | 2.8% |
| APGE APOGEE THERAPEUTICS INC | 1,308,113 | $173.6M | 2.7% |
| AMLX AMYLYX PHARMACEUTICALS INC | 8,334,882 | $149.7M | 2.3% |
| MGTX MEIRAGTX HLDGS PLC | 10,786,658 | $145.7M | 2.3% |
| ORKA ORUKA THERAPEUTICS INC | 1,345,063 | $128.0M | 2.0% |
| INBX INHIBRX BIOSCIENCES INC | 1,297,763 | $123.0M | 1.9% |
| PTGX PROTAGONIST THERAPEUTICS INC | 981,879 | $120.4M | 1.9% |
| SLDB SOLID BIOSCIENCES INC | 11,906,646 | $118.9M | 1.9% |
| ZYME ZYMEWORKS INC | 4,182,953 | $109.3M | 1.7% |
| TNGX TANGO THERAPEUTICS INC | 3,377,000 | $105.6M | 1.6% |
| IMTX IMMATICS N.V | 10,383,456 | $105.2M | 1.6% |
| NRIX NURIX THERAPEUTICS INC | 4,320,422 | $104.8M | 1.6% |
| BCRX BIOCRYST PHARMACEUTICALS INC | 10,308,888 | $103.1M | 1.6% |
| RVMD REVOLUTION MEDICINES INC | 777,600 | $101.2M | 1.6% |
| AVLN AVALYN PHARMACEUTICALS INC | 2,675,296 | $88.1M | 1.4% |
SEC FORM 13F · Q2 2026 · VALUES AS REPORTED, NOT PRICES
New positions this quarter
Held at 2026-06-30, not at 2026-03-31 · 21 in all · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| KARD KARDIGAN INC | 8,200,662 | $195.6M | 3.0% |
| AVLN AVALYN PHARMACEUTICALS INC | 2,675,296 | $88.1M | 1.4% |
| BIIB BIOGEN INC | 276,173 | $59.7M | 0.9% |
| UNH UNITEDHEALTH GROUP INC | 116,806 | $48.5M | 0.8% |
| CHARLES RIV LABS INTL INC | 140,000 | $31.8M | 0.5% |
| DHR DANAHER CORP DEL | 130,000 | $24.8M | 0.4% |
| ANL ADLAI NORTYE LTD | 1,793,190 | $20.6M | 0.3% |
| NVCT NUVECTIS PHARMA INC | 1,000,000 | $18.4M | 0.3% |
| MIRM MIRUM PHARMACEUTICALS INC | 115,391 | $13.5M | 0.2% |
| OSCR OSCAR HEALTH INC | 400,000 | $11.4M | 0.2% |
| SPTX SEAPORT THERAPEUTICS INC | 500,000 | $10.9M | 0.2% |
| BSX BOSTON SCIENTIFIC CORP | 250,000 | $10.7M | 0.2% |
| NTRA NATERA INC | 34,689 | $9.4M | 0.1% |
| RACC RESEARCH ALLIANCE CORP III | 750,000 | $8.0M | 0.1% |
| CGEM CULLINAN THERAPEUTICS INC | 426,478 | $7.8M | 0.1% |
| QURE UNIQURE NV | 168,000 | $7.7M | 0.1% |
| MOBI MOBIA MED INC | 523,654 | $7.0M | 0.1% |
| OTLK OUTLOOK THERAPEUTICS INC | 3,139,216 | $5.0M | <0.1% |
| XERS XERIS BIOPHARMA HOLDINGS INC | 467,013 | $3.7M | <0.1% |
| BDSX BIODESIX INC | 108,694 | $2.5M | <0.1% |
| KPRX KIORA PHARMACEUTICALS INC | 438,471 | $1.2M | <0.1% |
Sold out
Held at 2026-03-31, gone by 2026-06-30 · 11 in all · reported value as of 2026-03-31
| Holding | Shares 2026-03-31 | Reported value | % of portfolio then |
|---|---|---|---|
| CENTESSA PHARMACEUTICALS PLC | 10,517,806 | $417.8M | 4.1% |
| DAY ONE BIOPHARMACEUTICALS I | 3,511,598 | $75.3M | 0.7% |
| DRUG BRIGHT MINDS BIOSCIENCES INC | 755,088 | $55.1M | 0.5% |
| BLTE BELITE BIO INC | 303,958 | $48.5M | 0.5% |
| EVMN EVOMMUNE INC | 896,700 | $20.6M | 0.2% |
| NMRA NEUMORA THERAPEUTICS INC. | 10,208,194 | $19.9M | 0.2% |
| NBIX NEUROCRINE BIOSCIENCES INC | 130,100 | $17.1M | 0.2% |
| IRD OPUS GENETICS INC | 3,671,684 | $16.7M | 0.2% |
| IKT INHIBIKASE THERAPEUTICS INC | 4,630,000 | $7.8M | <0.1% |
| APELLIS PHARMACEUTICALS INC | 161,912 | $6.5M | <0.1% |
| PTN PALATIN TECHNOLOGIES INC | 123,890 | $2.2M | <0.1% |
Biggest increases and decreases
Positions held at both quarter ends, by change in shares · reported value as of 2026-06-30
Increases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| TNGX TANGO THERAPEUTICS INC | 1,616,306 | 3,377,000 | +108.9% | $105.6M |
| CORT CORCEPT THERAPEUTICS INC | 100,000 | 398,385 | +298.4% | $34.6M |
| ADPT ADAPTIVE BIOTECHNOLOGIES COR | 305,000 | 1,217,325 | +299.1% | $26.1M |
| IRTC IRHYTHM HOLDINGS INC | 210,052 | 223,766 | +6.5% | $26.6M |
Decreases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| PRAX PRAXIS PRECISION MEDICINES I | 4,071,972 | 2,035,986 | -50.0% | $681.6M |
| ASND ASCENDIS PHARMA A/S | 3,062,842 | 1,163,721 | -62.0% | $310.4M |
| CELC CELCUITY INC | 6,254,400 | 3,197,200 | -48.9% | $334.5M |
| ROIV ROIVANT SCIENCES LTD | 16,570,922 | 8,085,461 | -51.2% | $286.1M |
| SYRE SPYRE THERAPEUTICS INC | 7,566,450 | 4,319,496 | -42.9% | $383.5M |
| TVTX TRAVERE THERAPEUTICS INC | 8,285,102 | 3,752,574 | -54.7% | $213.2M |
| RYTM RHYTHM PHARMACEUTICALS INC | 4,747,590 | 2,586,295 | -45.5% | $287.2M |
| APGE APOGEE THERAPEUTICS INC | 3,080,768 | 1,308,113 | -57.5% | $173.6M |
| NUVL NUVALENT INC | 3,161,010 | 1,580,505 | -50.0% | $195.2M |
| EWTX EDGEWISE THERAPEUTICS INC | 8,847,948 | 4,373,974 | -50.6% | $177.7M |
| PTGX PROTAGONIST THERAPEUTICS INC | 2,461,758 | 981,879 | -60.1% | $120.4M |
| INBX INHIBRX BIOSCIENCES INC | 2,885,414 | 1,297,763 | -55.0% | $123.0M |
CIK 1224962 · 13F FILINGS ON EDGAR · INFORMATIONAL ONLY
