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WAVEMAN · COMPANY
SEPN · Septerna, Inc.
> Ask across nine datasets ⌘K
LIVE
TEAM-2.62% 13F +440META+1.00% 13F +2,694RCG+0.35% CLUSTERUTHR-0.54% 13F +425CRWV+5.68% 13F +694CRM-1.97% 13F +1,019CVNA+1.58% 13F +795TPL-1.11% 13F +444NET-1.96% 13F +711MSTR-1.39% 13F +527DELL+1.50% 13F +1,204CRWD-0.87% 13F +1,383ANET+1.22% 13F +1,324COIN-4.18% 13F +475TEAM-2.62% 13F +440META+1.00% 13F +2,694RCG+0.35% CLUSTERUTHR-0.54% 13F +425CRWV+5.68% 13F +694CRM-1.97% 13F +1,019CVNA+1.58% 13F +795TPL-1.11% 13F +444NET-1.96% 13F +711MSTR-1.39% 13F +527DELL+1.50% 13F +1,204CRWD-0.87% 13F +1,383ANET+1.22% 13F +1,324COIN-4.18% 13F +475
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SEPN

Septerna, Inc.
PHARMA & BIOTECH · PHARMACEUTICAL PREPARATIONS · CIK 0001984086
FORM 144 · 8☆ WATCH
INSIDER NET · 180D
-$42.2M
open-market buys minus sells, Form 4 codes P and S
INSIDER BUYERS · 180D
0
CONGRESS BUYERS · 1Y
0
FUNDS ADDED · QTR
97
13F, latest reported quarter
REVENUE GROWTH
+4174.5%
XBRL, annual
NET MARGIN
-106.4%
CONVERSIONS · 180D
16
codes C/M, not in net · $487.5K priced
SEVEN FACTS, RANKED AGAINST THE SECTOR · RANK IS NOT A FORECAST
INSIDERS
net -$42.2M over 180 days
-$41.5M over 90 days · -$39.1M of it by a 10%+ holder
below 93% of Pharma & Biotech
CONGRESS
no member of Congress has reported trading it
FUNDS
97 funds added or opened last quarter
more than 64% of Pharma & Biotech
REVENUE
+4174.5% year over year
more than 98% of Pharma & Biotech
MARGIN
-106.4% net margin
below 66% of Pharma & Biotech
BUYBACKS
no share repurchases reported
SHORT
no short interest reported
THE SITUATION · EVERY LINE IS ONE RULE OVER ONE DATASET
Insiders are net sellers: -$42.2M across 5 people in 180 days.
97 funds added or opened positions in the latest 13F quarter, of 156 holders.
The year, with the filings on it
Total return indexed to 100 over the last 12 months · every marker is a federal filing, placed at its date — hover any marker for the detail
TOTAL 12M RETURN +197.8%
+197.8%12M
+0%+97%+194%+291%2025-092025-102025-122026-032026-052026-072026-09 2026-08-12 · RA CAPITAL MANAGEMENT, L.P. sold $31.7M2026-08-12 · Third Rock Ventures V, L.P. sold $7.4M2026-03-02 · Shaikhly Samira sold $1.9M2026-08-11 · Bhatt Elizabeth sold $1.1M2026-05-26 · Shaikhly Samira sold $354.6K2026-06-22 · Long Daniel D. sold $280.8K2026-06-22 · Long Daniel D. sold $251.8K2026-06-12 · Shaikhly Samira sold $219.2K2026-07-15 · Bhatt Elizabeth sold $136.0K2026-09-01 · Long Daniel D. sold $126.1K2026-03-02 · Shaikhly Samira sold $112.5K2026-06-01 · Shaikhly Samira sold $85.7K2026-08-03 · Long Daniel D. sold $80.9K2026-06-29 · Shaikhly Samira sold $76.6K2026-07-01 · Long Daniel D. sold $71.6K2025-11-10 · Long Daniel D. sold $63.2K2026-02-18 · Bhatt Elizabeth sold $62.6K2026-04-15 · Bhatt Elizabeth sold $61.1K2026-02-18 · Bhatt Elizabeth sold $53.2K2026-06-01 · Shaikhly Samira sold $47.2K2026-07-01 · Long Daniel D. sold $42.9K2026-06-01 · Shaikhly Samira sold $38.8K2026-08-03 · Long Daniel D. sold $34.0K2026-04-15 · Bhatt Elizabeth sold $27.8K2026-04-15 · Bhatt Elizabeth sold $8.4K2026-08-12 · Third Rock Ventures V, L.P. sold $7.2K2026-08-12 · RA Capital Healthcare Fund LP filed to sell $36.0M2026-08-12 · RA Capital Nexus Fund III, L.P. filed to sell $36.0M2026-08-12 · Third Rock Ventures V, L.P. filed to sell $7.5M2026-08-11 · ELIZABETH P. BHATT filed to sell $1.1M2026-07-15 · ELIZABETH P. BHATT filed to sell $138.2K2026-06-26 · JAE KIM filed to sell $89.2K2026-06-22 · JAE KIM filed to sell $3.3M2026-06-22 · DANIEL LONG filed to sell $904.2K
INSIDER SELLFORM 144
INDEXED RETURN, DIVIDEND-ADJUSTED — NOT A PRICE CHART · LARGE TRADES DRAWN FIRST WHEN A NAME FILES HEAVILY
Live price
Daily candles from TradingView, on their licence — no filings are marked on this one
WHY THIS NAME IS ON THE DESK
Insiders have filed to sell — before selling.
The record shows a net $42.2M sold by insiders over 180 days, 97 funds added last quarter, $85.0M in planned Form 144 sales. Every figure is a federal filing, dated the day it became public.
Backtest this pattern Open the screener
Same sector, ranked by filing activity
Sector from the SEC's own SIC classification
UTHRCPIXMRNAREGNLLYALNYELFCITRMDGLDNAVRTXNUVL
Insider transactions
Form 4 purchases and sales (codes P and S) — grants, option exercises and preferred conversions excluded

Over the last 180 days, Septerna, Inc. insiders sold a net $42.2M of stock across 45 Form 4 purchases and sales, with 0 insider(s) buying. Source: SEC Form 4 filings, as of 2026-09-06.

INSIDER
FILED
SHARES
VALUE
Long Daniel D.
SVP, Drug Discovery
SELL
2026-09-01
3,333.0
$126.1K
RA CAPITAL MANAGEMENT, L.P.
Director
SELL
2026-08-12
746,500.0
$31.7M
Third Rock Ventures V, L.P.
—
SELL
2026-08-12
147,059.0
$7.4M
Third Rock Ventures V, L.P.
—
SELL
2026-08-12
141.0
$7.2K
Bhatt Elizabeth
President and COO
SELL
2026-08-11
25,000.0
$1.1M
45 TRANSACTIONS ON RECORD

Showing the most recent few. Create a free account to see 40 more transactions on record, the cross-source screener and CSV export. We store only your email address, and there is no password to create.

Institutional holders
13F · holdings as of the latest quarter funds have reported
RA CAPITAL MANAGEMENT, L.P.
6,995,858.0 sh
$234.3M
TRV GP V, LLC
6,215,591.0 sh
$208.2M
Driehaus Capital Management LLC
4,433,058.0 sh
$148.5M
TRV GP VI, LLC
4,211,659.0 sh
$141.0M
SAMSARA BIOCAPITAL, LLC
3,149,128.0 sh
$105.5M
SCHEDULE 13D/G
No 5%+ ownership filings
Nobody has crossed 5% with a filing obligation. Absence is a fact here, not missing data.
Planned sales · Form 144
Filed before the sale — intent, not a trade
RA Capital Healthcare Fund LP
FILED 2026-08-12
$36.0M
RA Capital Nexus Fund III, L.P.
FILED 2026-08-12
$36.0M
Third Rock Ventures V, L.P.
FILED 2026-08-12
$7.5M
ELIZABETH P. BHATT
FILED 2026-08-11
$1.1M
ELIZABETH P. BHATT
FILED 2026-07-15
$138.2K
Fund concentration
N-PORT · funds ranked by how much of THEMSELVES they put in this stock — the conviction number 13F cannot show
State Street(R) SPDR(R) S&P(R) Pharmaceuticals ETF
$3.1M POSITION · AS OF 2026-03-31
1.0%
PROFUND VP PHARMACEUTICALS
$98.1K POSITION · AS OF 2026-03-31
1.0%
Driehaus Micro Cap Growth Fund
$3.8M POSITION · AS OF 2026-03-31
0.8%
Driehaus Small Cap Growth Fund
$9.1M POSITION · AS OF 2026-03-31
0.8%
Direxion Daily Pharmaceutical & Medical Bull 3X Shares
$89.3K POSITION · AS OF 2026-04-30
0.7%
Virtus Biotech Clinical Trials Etf
$257.8K POSITION · AS OF 2026-04-30
0.7%
SEC N-PORT, MONTHLY WITH A ~60-DAY PUBLIC LAG · FUNDS ≥ $10M · % = SHARE OF THE FUND'S OWN BOOK
Clinical pipeline
ClinicalTrials.gov · 2 registered trials, 1 still enrolling or running — a status change here is dated weeks before the press release
2
Phase 1
1 ACTIVE
TRIALS MATCHED TO THIS TICKER BY SPONSOR NAME · STUDIES RUN UNDER A SUBSIDIARY'S OWN NAME ARE NOT INCLUDED
Fundamentals
Annual figures from XBRL filings · pick a past date to see them exactly as the market knew them then — restatements and all
2025-122024-122023-12
REVENUE$46.0M$1.1M$151.0K
OPERATING INCOME$-68.3M$-80.8M$2.1M
NET INCOME$-48.9M$-71.8M$4.2M
EPS (DILUTED)-1.10-7.260.29
OPERATING CASH FLOW$110.2M$-67.5M$-38.7M
CASH$120.7M$238.2M$88.5M
SEC XBRL · FISCAL-YEAR PERIODS · AS KNOWN ON 2026-09-06 · NOBODY ELSE SHOWS FUNDAMENTALS AS OF A PAST DATE
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Public filings, honestly analyzed. Official US government sources in one desk — every figure carries the date it was filed, and the methodology is published, backtest included.

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