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PRLD · Prelude Therapeutics Inc

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TEAM-0.32% 13F +439META+2.47% 13F +2,694RCG-2.04% CLUSTERUTHR-4.03% 13F +425CRWV-1.12% 13F +693CRM-0.46% 13F +1,018CVNA+2.74% 13F +794TPL-0.71% 13F +444NET-4.47% 13F +710MSTR-1.35% 13F +526DELL+15.81% 13F +1,203CRWD-5.42% 13F +1,382ANET+2.87% 13F +1,323COIN-1.05% 13F +475TEAM-0.32% 13F +439META+2.47% 13F +2,694RCG-2.04% CLUSTERUTHR-4.03% 13F +425CRWV-1.12% 13F +693CRM-0.46% 13F +1,018CVNA+2.74% 13F +794TPL-0.71% 13F +444NET-4.47% 13F +710MSTR-1.35% 13F +526DELL+15.81% 13F +1,203CRWD-5.42% 13F +1,382ANET+2.87% 13F +1,323COIN-1.05% 13F +475

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PRLD

Name: Prelude Therapeutics Inc (PRLD) insider trading and ownership data
Creator: WaveMan
License: https://wave-man.com/terms

Prelude Therapeutics Inc

PHARMA & BIOTECH · PHARMACEUTICAL PREPARATIONS · CIK 0001678660

SEC FILINGS☆ WATCH

INSIDER NET · 180D

$25.0M

open-market buys minus sells, Form 4 codes P and S

INSIDER BUYERS · 180D

CONGRESS BUYERS · 1Y

FUNDS ADDED · QTR

13F, latest reported quarter

REVENUE GROWTH

+73.4%

XBRL, annual

NET MARGIN

-819.6%

SEVEN FACTS, RANKED AGAINST THE SECTOR · RANK IS NOT A FORECAST

INSIDERS

net +$25.0M over 180 days

+$25.0M of it by a 10%+ holder

more than 97% of Pharma & Biotech

CONGRESS

no member of Congress has reported trading it

FUNDS

60 funds added or opened last quarter

below 51% of Pharma & Biotech

REVENUE

+73.4% year over year

more than 83% of Pharma & Biotech

MARGIN

-819.6% net margin

below 87% of Pharma & Biotech

BUYBACKS

no share repurchases reported

SHORT

no short interest reported

THE SITUATION · EVERY LINE IS ONE RULE OVER ONE DATASET

60 funds added or opened positions in the latest 13F quarter, of 77 holders.

The year, with the filings on it

Total return indexed to 100 over the last 12 months · every marker is a federal filing, placed at its date — hover any marker for the detail

TOTAL 12M RETURN +380.5%

+380.5%12M

INSIDER BUY

INDEXED RETURN, DIVIDEND-ADJUSTED — NOT A PRICE CHART · LARGE TRADES DRAWN FIRST WHEN A NAME FILES HEAVILY

Live price

Daily candles from TradingView, on their licence — no filings are marked on this one

WHY THIS NAME IS ON THE DESK

Insiders are net buyers of their own stock.

The record shows a net $25.0M bought by insiders over 180 days, 60 funds added last quarter. Every figure is a federal filing, dated the day it became public.

Backtest this pattern Open the screener

Same sector, ranked by filing activity

Sector from the SEC's own SIC classification

UTHR CPIX MRNA REGN LLY ALNY ELF CITR MDGL DNA VRTX NUVL

Insider transactions

Form 4 purchases and sales (codes P and S) — grants, option exercises and preferred conversions excluded

Over the last 180 days, Prelude Therapeutics Inc insiders bought a net $25.0M of stock across 61 Form 4 purchases and sales, with 2 insider(s) buying. Source: SEC Form 4 filings, as of 2026-09-04.

INSIDER

FILED

VALUE

Bonita David P

Director

BUY

2026-04-21

1,689,189.0

$7.5M

Bonita David P

Director

BUY

2026-04-21

1,126,126.0

$5.0M

OrbiMed Genesis GP LLC

Director

BUY

2026-04-21

1,689,189.0

$7.5M

OrbiMed Genesis GP LLC

Director

BUY

2026-04-21

1,126,126.0

$5.0M

Combs Andrew

Chief Chemistry Officer

BUY

2025-03-25

100,000.0

$69.0K

61 TRANSACTIONS ON RECORD

Showing the most recent few. Create a free account to see 56 more transactions on record, the cross-source screener and CSV export. We store only your email address, and there is no password to create.

Institutional holders

13F · holdings as of the latest quarter funds have reported

ORBIMED ADVISORS LLC

13,724,571.0 sh

$73.2M

BAKER BROS. ADVISORS LP

10,123,824.0 sh

$54.0M

RA CAPITAL MANAGEMENT, L.P.

6,475,882.0 sh

$34.5M

Soleus Capital Management, L.P.

3,378,378.0 sh

$18.0M

Kynam Capital Management, LP

2,415,087.0 sh

$12.9M

SCHEDULE 13D/G

No 5%+ ownership filings

Nobody has crossed 5% with a filing obligation. Absence is a fact here, not missing data.

FORM 144

No planned-sale notices

No insider has notified an intent to sell. This is the panel to watch after a run-up.

Fund concentration

N-PORT · funds ranked by how much of THEMSELVES they put in this stock — the conviction number 13F cannot show

Ultra-Small Company Market Fund

$171.0K POSITION · AS OF 2026-03-31

0.1%

JNL/DFA U.S. Small Cap Fund

$12.0K POSITION · AS OF 2026-03-31

0.0%

Avantis U.S. Small Cap Equity ETF

$28.4K POSITION · AS OF 2026-02-28

0.0%

VANGUARD EXTENDED MARKET INDEX FUND

$900.0K POSITION · AS OF 2026-03-31

0.0%

Fidelity Extended Market Index Fund

$360.6K POSITION · AS OF 2026-02-28

0.0%

Dimensional US Sustainability Core 1 ETF

$17.4K POSITION · AS OF 2026-04-30

0.0%

SEC N-PORT, MONTHLY WITH A ~60-DAY PUBLIC LAG · FUNDS ≥ $10M · % = SHARE OF THE FUND'S OWN BOOK

Clinical pipeline

ClinicalTrials.gov · 11 registered trials, 1 still enrolling or running — a status change here is dated weeks before the press release

Phase 1

1 ACTIVE

Phase 2

0 ACTIVE

TRIALS MATCHED TO THIS TICKER BY SPONSOR NAME · STUDIES RUN UNDER A SUBSIDIARY'S OWN NAME ARE NOT INCLUDED

Executive pay vs shareholder return

DEF 14A pay-versus-performance disclosure · both the headline pay and the SEC's mark-to-market figure, beside the return the company delivered and the return of the peer group it chose itself

CEO TOTAL

ACTUALLY PAID

OTHER NEOs AVG

TSR

PEER TSR

2025

$1.3M

$2.4M

$833.6K

-32%

—

2024

$2.3M

$448.0K

$1.3M

-70%

—

TAGGED BY THE COMPANY UNDER SEC ITEM 402(v) · RETURN IS CUMULATIVE FROM THE START OF THE DISCLOSURE PERIOD · GREEN WHERE THE COMPANY BEAT ITS OWN PEER GROUP

Fundamentals

Annual figures from XBRL filings · pick a past date to see them exactly as the market knew them then — restatements and all

	2025-12	2024-12	2023-12	2022-12
REVENUE	$12.1M	$7.0M	—	—
OPERATING INCOME	$-104.6M	$-139.7M	$-132.3M	$-123.5M
NET INCOME	$-99.5M	$-127.2M	$-121.8M	$-115.4M
EPS (DILUTED)	-1.29	-1.68	-2.02	-2.44
OPERATING CASH FLOW	$-56.3M	$-102.9M	$-107.1M	$-83.7M
CASH	$35.3M	$12.5M	$25.3M	$30.6M

SEC XBRL · FISCAL-YEAR PERIODS · AS KNOWN ON 2026-09-04 · NOBODY ELSE SHOWS FUNDAMENTALS AS OF A PAST DATE