Sphera Funds Management LTD. 13F holdings
Sphera Funds Management LTD. reported 97 positions with a total reported value of $698.8M as of 2026-06-30, in its 13F for Q2 2026, filed 2026-08-14. Top holdings by reported value: TEVA TEVA PHARMACEUTICAL INDS LTD (7.3%), MLYS MINERALYS THERAPEUTICS INC (5.7%), TSEM TOWER SEMICONDUCTOR LTD (4.0%), SNDX SYNDAX PHARMACEUTICALS INC (3.2%), BIIB BIOGEN INC (3.0%). Against 2026-03-31 it opened 22 new positions and exited 16. Next 13F due by 2026-11-14, the legal deadline 45 days after the quarter ending 2026-09-30.
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Top holdings
25 largest of 97 positions · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| TEVA TEVA PHARMACEUTICAL INDS LTD | 1,500,082 | $50.8M | 7.3% |
| MLYS MINERALYS THERAPEUTICS INC | 1,469,971 | $39.7M | 5.7% |
| TSEM TOWER SEMICONDUCTOR LTD | 108,265 | $28.2M | 4.0% |
| SNDX SYNDAX PHARMACEUTICALS INC | 1,014,606 | $22.2M | 3.2% |
| BIIB BIOGEN INC | 96,626 | $20.9M | 3.0% |
| RARE ULTRAGENYX PHARMACEUTICAL IN | 588,494 | $19.6M | 2.8% |
| BMRN BIOMARIN PHARMACEUTICAL INC | 328,550 | $18.8M | 2.7% |
| CYTK CYTOKINETICS INC | 219,987 | $18.7M | 2.7% |
| BBIO BRIDGEBIO PHARMA INC | 245,346 | $18.3M | 2.6% |
| COGT COGENT BIOSCIENCES INC | 459,340 | $17.8M | 2.5% |
| NVMI NOVA LTD | 25,169 | $13.7M | 2.0% |
| INSM INSMED INC | 118,800 | $12.7M | 1.8% |
| MAZE MAZE THERAPEUTICS INC | 417,564 | $12.5M | 1.8% |
| AZN ASTRAZENECA PLC | 62,530 | $11.9M | 1.7% |
| SNY SANOFI SA | 269,515 | $11.5M | 1.6% |
| CYBIN INC | 1,620,753 | $10.7M | 1.5% |
| LLY ELI LILLY & CO | 8,040 | $9.6M | 1.4% |
| MDGL MADRIGAL PHARMACEUTICALS INC | 17,419 | $9.4M | 1.3% |
| TRVI TREVI THERAPEUTICS INC | 499,029 | $9.3M | 1.3% |
| ACAD ACADIA PHARMACEUTICALS INC | 356,534 | $9.0M | 1.3% |
| CLDX CELLDEX THERAPEUTICS INC NEW | 240,868 | $9.0M | 1.3% |
| RYTM RHYTHM PHARMACEUTICALS INC | 80,400 | $8.9M | 1.3% |
| ORIC ORIC PHARMACEUTICALS INC | 752,983 | $8.2M | 1.2% |
| LRCX LAM RESEARCH CORP | 18,470 | $8.0M | 1.1% |
| APPLIED MATLS INC | 11,040 | $8.0M | 1.1% |
SEC FORM 13F · Q2 2026 · VALUES AS REPORTED, NOT PRICES
New positions this quarter
Held at 2026-06-30, not at 2026-03-31 · 22 in all · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| INSM INSMED INC | 118,800 | $12.7M | 1.8% |
| RYTM RHYTHM PHARMACEUTICALS INC | 80,400 | $8.9M | 1.3% |
| LRCX LAM RESEARCH CORP | 18,470 | $8.0M | 1.1% |
| APPLIED MATLS INC | 11,040 | $8.0M | 1.1% |
| IDYA IDEAYA BIOSCIENCES INC | 196,408 | $7.3M | 1.0% |
| NVCT NUVECTIS PHARMA INC | 382,945 | $7.0M | 1.0% |
| HRMY HARMONY BIOSCIENCES HLDGS IN | 176,663 | $6.4M | 0.9% |
| VST VISTRA CORP | 29,450 | $4.7M | 0.7% |
| TLN TALEN ENERGY CORP | 12,135 | $4.7M | 0.7% |
| GLOBAL X FDS | 195,900 | $4.5M | 0.6% |
| AVTX AVALO THERAPEUTICS INC | 232,294 | $4.3M | 0.6% |
| CABA CABALETTA BIO INC | 1,329,012 | $4.1M | 0.6% |
| BBOT BRIDGEBIO ONCOLOGY THERAPEUT | 460,985 | $3.5M | 0.5% |
| PROQR THRAPEUTICS N V | 1,757,458 | $3.3M | 0.5% |
| ALNY ALNYLAM PHARMACEUTICALS INC | 10,800 | $3.3M | 0.5% |
| LRMR LARIMAR THERAPEUTICS INC | 926,004 | $2.8M | 0.4% |
| IMMX IMMIX BIOPHARMA INC | 270,000 | $2.8M | 0.4% |
| CEG CONSTELLATION ENERGY CORP | 9,850 | $2.4M | 0.4% |
| TSHA TAYSHA GENE THERAPIES INC | 250,000 | $1.7M | 0.2% |
| IKT INHIBIKASE THERAPEUTICS INC | 649,309 | $1.3M | 0.2% |
| TRAX FIRST TRACKS BIOTHERAPEUTICS | 27,876 | $560.9K | <0.1% |
| TRAW TRAWS PHARMA INC | 398,486 | $336.0K | <0.1% |
Sold out
Held at 2026-03-31, gone by 2026-06-30 · 16 in all · reported value as of 2026-03-31
| Holding | Shares 2026-03-31 | Reported value | % of portfolio then |
|---|---|---|---|
| AMICUS THERAPEUTIC | 603,377 | $8.7M | 1.5% |
| CLBT CELLEBRITE DI LTD | 631,521 | $8.7M | 1.5% |
| APELLIS PHARMACEUTICALS INC | 214,914 | $8.6M | 1.5% |
| PANW PALO ALTO NETWORKS INC | 52,800 | $8.5M | 1.5% |
| CAMT CAMTEK LTD | 53,020 | $8.0M | 1.4% |
| SOLENO THERAPEUTICS INC | 216,281 | $7.2M | 1.2% |
| AMZN AMAZON COM INC | 31,940 | $6.7M | 1.1% |
| AAOI APPLIED OPTOELECTRONICS INC | 73,400 | $6.2M | 1.1% |
| ENPH ENPHASE ENERGY INC | 142,419 | $5.4M | 0.9% |
| ZIM ZIM INTEGRATED SHIPPING SERV | 105,950 | $2.8M | 0.5% |
| IBIT ISHARES BITCOIN TRUST ETF | 59,505 | $2.3M | 0.4% |
| ASND ASCENDIS PHARMA A/S | 8,000 | $1.8M | 0.3% |
| BMY BRISTOL-MYERS SQUIBB CO | 17,500 | $1.1M | 0.2% |
| NICE NICE LTD | 5,611 | $618.7K | 0.1% |
| DTIL PRECISION BIOSCIENCES INC | 40,000 | $220.0K | <0.1% |
| FHTX FOGHORN THERAPEUTICS INC | 12,224 | $58.4K | <0.1% |
Biggest increases and decreases
Positions held at both quarter ends, by change in shares · reported value as of 2026-06-30
Increases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| CYTK CYTOKINETICS INC | 39,817 | 219,987 | +452.5% | $18.7M |
| TEVA TEVA PHARMACEUTICAL INDS LTD | 1,136,975 | 1,500,082 | +31.9% | $50.8M |
| BMRN BIOMARIN PHARMACEUTICAL INC | 139,900 | 328,550 | +134.8% | $18.8M |
| SNDX SYNDAX PHARMACEUTICALS INC | 724,563 | 1,014,606 | +40.0% | $22.2M |
| MAZE MAZE THERAPEUTICS INC | 227,343 | 417,564 | +83.7% | $12.5M |
| MDGL MADRIGAL PHARMACEUTICALS INC | 9,040 | 17,419 | +92.7% | $9.4M |
| CYBIN INC | 987,090 | 1,620,753 | +64.2% | $10.7M |
| MLYS MINERALYS THERAPEUTICS INC | 1,339,971 | 1,469,971 | +9.7% | $39.7M |
| BIOA BIOAGE LABS INC | 86,518 | 213,671 | +147.0% | $5.2M |
| ACAD ACADIA PHARMACEUTICALS INC | 256,202 | 356,534 | +39.2% | $9.0M |
| CTMX CYTOMX THERAPEUTICS INC. | 220,000 | 879,000 | +299.5% | $3.3M |
| PRLD PRELUDE THERAPEUTICS INC | 558,339 | 1,019,832 | +82.7% | $5.4M |
Decreases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| CRIS CURIS INC | 1,994,937 | 98,996 | -95.0% | $1.0M |
| NVMI NOVA LTD | 53,366 | 25,169 | -52.8% | $13.7M |
| TSEM TOWER SEMICONDUCTOR LTD | 145,735 | 108,265 | -25.7% | $28.2M |
| RARE ULTRAGENYX PHARMACEUTICAL IN | 809,333 | 588,494 | -27.3% | $19.6M |
| BHVN BIOHAVEN LTD | 594,000 | 164,437 | -72.3% | $2.4M |
| RVMD REVOLUTION MEDICINES INC | 55,110 | 22,400 | -59.4% | $4.2M |
| BCRX BIOCRYST PHARMACEUTICALS INC | 866,464 | 422,051 | -51.3% | $4.2M |
| ORA ORMAT TECHNOLOGIES INC | 68,250 | 28,015 | -59.0% | $3.1M |
| RLAY RELAY THERAPEUTICS INC | 408,436 | 233,836 | -42.7% | $4.4M |
| TNGX TANGO THERAPEUTICS INC | 343,563 | 254,250 | -26.0% | $7.9M |
| ELDN ELEDON PHARMACEUTICALS INC | 1,772,131 | 1,191,187 | -32.8% | $4.7M |
| ELVN ENLIVEN THERAPEUTICS INC | 153,265 | 112,765 | -26.4% | $5.7M |
CIK 1496201 · 13F FILINGS ON EDGAR · INFORMATIONAL ONLY
