Deerfield Management Company, L.P. 13F holdings
Deerfield Management Company, L.P. reported 70 positions with a total reported value of $8.0B as of 2026-06-30, in its 13F for Q2 2026, filed 2026-08-14. Top holdings by reported value: NUVL NUVALENT INC (26.5%), RVMD REVOLUTION MEDICINES INC (5.6%), PRAX PRAXIS PRECISION MEDICINES I (4.0%), VTRS VIATRIS INC (4.0%), CNC CENTENE CORP DEL (3.9%). Against 2026-03-31 it opened 11 new positions and exited 12. Next 13F due by 2026-11-14, the legal deadline 45 days after the quarter ending 2026-09-30.
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Top holdings
25 largest of 70 positions · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| NUVL NUVALENT INC | 17,248,450 | $2.1B | 26.5% |
| RVMD REVOLUTION MEDICINES INC | 2,392,000 | $448.0M | 5.6% |
| PRAX PRAXIS PRECISION MEDICINES I | 963,351 | $322.5M | 4.0% |
| VTRS VIATRIS INC | 20,206,170 | $320.9M | 4.0% |
| CNC CENTENE CORP DEL | 4,901,000 | $314.6M | 3.9% |
| UTHR UNITED THERAPEUTICS CORP DEL | 457,000 | $247.6M | 3.1% |
| LEGN LEGEND BIOTECH CORP | 8,137,638 | $235.0M | 2.9% |
| COGT COGENT BIOSCIENCES INC | 5,006,104 | $193.7M | 2.4% |
| GMAB GENMAB A/S | 6,865,000 | $188.6M | 2.3% |
| BKD BROOKDALE SR LIVING INC | 11,637,032 | $187.2M | 2.3% |
| VERA VERA THERAPEUTICS INC | 3,916,400 | $168.1M | 2.1% |
| IONS IONIS PHARMACEUTICALS INC | 1,979,669 | $157.0M | 2.0% |
| CELC CELCUITY INC | 1,451,014 | $151.8M | 1.9% |
| BCRX BIOCRYST PHARMACEUTICALS INC | 15,096,403 | $151.0M | 1.9% |
| NAMS NEWAMSTERDAM PHARMA COMPANY | 4,357,576 | $146.5M | 1.8% |
| ACHC ACADIA HEALTHCARE COMPANY IN | 4,520,000 | $133.5M | 1.7% |
| TNGX TANGO THERAPEUTICS INC | 4,190,611 | $131.0M | 1.6% |
| AHCO ADAPTHEALTH CORP | 11,477,730 | $119.6M | 1.5% |
| PHVS PHARVARIS N V | 3,376,042 | $116.7M | 1.5% |
| ARWR ARROWHEAD PHARMACEUTICALS IN | 1,389,055 | $113.2M | 1.4% |
| DNTH DIANTHUS THERAPEUTICS INC | 1,125,313 | $109.7M | 1.4% |
| LRMR LARIMAR THERAPEUTICS INC | 35,606,974 | $108.6M | 1.4% |
| MLYS MINERALYS THERAPEUTICS INC | 3,958,000 | $106.8M | 1.3% |
| IDYA IDEAYA BIOSCIENCES INC | 2,714,503 | $101.2M | 1.3% |
| XENE XENON PHARMACEUTICALS INC | 1,615,696 | $97.5M | 1.2% |
SEC FORM 13F · Q2 2026 · VALUES AS REPORTED, NOT PRICES
New positions this quarter
Held at 2026-06-30, not at 2026-03-31 · 11 in all · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| MLYS MINERALYS THERAPEUTICS INC | 3,958,000 | $106.8M | 1.3% |
| BSX BOSTON SCIENTIFIC CORP | 1,315,000 | $56.1M | 0.7% |
| PBLS PARABILIS MEDICINES INC | 1,880,704 | $51.5M | 0.6% |
| AVLN AVALYN PHARMACEUTICALS INC | 731,000 | $24.1M | 0.3% |
| ODTX ODYSSEY THERAPEUTICS INC | 1,046,139 | $19.6M | 0.2% |
| ALMR ALAMAR BIOSCIENCES INC | 600,000 | $16.3M | 0.2% |
| CHE CHEMED CORP NEW | 30,000 | $14.0M | 0.2% |
| ADAG ADAGENE INC | 2,666,666 | $11.2M | 0.1% |
| COAG HEMAB THERAPEUTICS HLDGS INC | 275,000 | $10.1M | 0.1% |
| MOBI MOBIA MED INC | 670,752 | $9.0M | 0.1% |
| MIRM MIRUM PHARMACEUTICALS INC | 6,027 | $705.6K | <0.1% |
Sold out
Held at 2026-03-31, gone by 2026-06-30 · 12 in all · reported value as of 2026-03-31
| Holding | Shares 2026-03-31 | Reported value | % of portfolio then |
|---|---|---|---|
| CPRX CATALYST PHARMACEUTICALS INC | 3,943,600 | $97.6M | 1.4% |
| NBIX NEUROCRINE BIOSCIENCES INC | 610,000 | $80.4M | 1.1% |
| DAY ONE BIOPHARMACEUTICALS I | 3,723,131 | $79.8M | 1.1% |
| ENHABIT INC | 4,747,746 | $66.9M | 0.9% |
| KYMR KYMERA THERAPEUTICS INC | 561,170 | $46.7M | 0.7% |
| CMPX COMPASS THERAPEUTICS INC | 3,606,000 | $19.1M | 0.3% |
| TSHA TAYSHA GENE THERAPIES INC | 2,722,165 | $12.2M | 0.2% |
| CGEM CULLINAN THERAPEUTICS INC | 386,169 | $5.5M | <0.1% |
| BIOMX INC | 131,272 | $492.8K | <0.1% |
| MANE VERADERMICS INC | 5,000 | $315.8K | <0.1% |
| QSI QUANTUM SI INC | 333,333 | $36.2K | <0.1% |
| MYGN MYRIAD GENETICS INC | 505 | $2.3K | <0.1% |
Biggest increases and decreases
Positions held at both quarter ends, by change in shares · reported value as of 2026-06-30
Increases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| GMAB GENMAB A/S | 2,462,000 | 6,865,000 | +178.8% | $188.6M |
| IDYA IDEAYA BIOSCIENCES INC | 1,530,008 | 2,714,503 | +77.4% | $101.2M |
| BMRN BIOMARIN PHARMACEUTICAL INC | 851,556 | 1,332,836 | +56.5% | $76.3M |
| RVMD REVOLUTION MEDICINES INC | 2,297,000 | 2,392,000 | +4.1% | $448.0M |
| GPCR STRUCTURE THERAPEUTICS INC | 767,993 | 1,086,000 | +41.4% | $58.3M |
| TYRA TYRA BIOSCIENCES INC | 549,000 | 1,017,000 | +85.2% | $32.5M |
| LEGN LEGEND BIOTECH CORP | 7,687,638 | 8,137,638 | +5.9% | $235.0M |
| DNTH DIANTHUS THERAPEUTICS INC | 1,019,813 | 1,125,313 | +10.3% | $109.7M |
| PHVS PHARVARIS N V | 3,126,042 | 3,376,042 | +8.0% | $116.7M |
| VERA VERA THERAPEUTICS INC | 3,722,100 | 3,916,400 | +5.2% | $168.1M |
| BLTE BELITE BIO INC | 304,013 | 357,199 | +17.5% | $55.0M |
| TNGX TANGO THERAPEUTICS INC | 4,146,813 | 4,190,611 | +1.1% | $131.0M |
Decreases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| COGT COGENT BIOSCIENCES INC | 9,043,903 | 5,006,104 | -44.6% | $193.7M |
| CNC CENTENE CORP DEL | 5,917,091 | 4,901,000 | -17.2% | $314.6M |
| INSPIRE MED SYS INC | 2,703,238 | 1,296,862 | -52.0% | $57.9M |
| INDV INDIVIOR PHARMACEUTICALS INC | 3,097,790 | 1,648,895 | -46.8% | $67.7M |
| VCYT VERACYTE INC | 726,000 | 101,000 | -86.1% | $5.9M |
| CELC CELCUITY INC | 1,714,000 | 1,451,014 | -15.3% | $151.8M |
| ARWR ARROWHEAD PHARMACEUTICALS IN | 1,573,297 | 1,389,055 | -11.7% | $113.2M |
| SION SIONNA THERAPEUTICS INC | 970,590 | 680,916 | -29.8% | $30.0M |
| LNTH LANTHEUS HLDGS INC | 827,999 | 752,999 | -9.1% | $83.5M |
| CDNA CAREDX INC | 2,191,000 | 1,997,618 | -8.8% | $56.9M |
| CERT CERTARA INC | 7,808,605 | 7,512,928 | -3.8% | $49.2M |
CIK 1009258 · 13F FILINGS ON EDGAR · INFORMATIONAL ONLY
