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UPB · Upstream Bio, Inc.
> Ask across nine datasets ⌘K
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TEAM-0.32% 13F +439META+2.47% 13F +2,694RCG-2.04% CLUSTERUTHR-4.03% 13F +425CRWV-1.12% 13F +693CRM-0.46% 13F +1,018CVNA+2.74% 13F +794TPL-0.71% 13F +444NET-4.47% 13F +710MSTR-1.35% 13F +526DELL+15.81% 13F +1,203CRWD-5.42% 13F +1,382ANET+2.87% 13F +1,323COIN-1.05% 13F +475TEAM-0.32% 13F +439META+2.47% 13F +2,694RCG-2.04% CLUSTERUTHR-4.03% 13F +425CRWV-1.12% 13F +693CRM-0.46% 13F +1,018CVNA+2.74% 13F +794TPL-0.71% 13F +444NET-4.47% 13F +710MSTR-1.35% 13F +526DELL+15.81% 13F +1,203CRWD-5.42% 13F +1,382ANET+2.87% 13F +1,323COIN-1.05% 13F +475
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UPB

Upstream Bio, Inc.
PHARMA & BIOTECH · PHARMACEUTICAL PREPARATIONS · CIK 0002022626
SEC FILINGS☆ WATCH
INSIDER NET · 180D
-$77.2K
open-market buys minus sells, Form 4 codes P and S
INSIDER BUYERS · 180D
0
CONGRESS BUYERS · 1Y
0
FUNDS ADDED · QTR
103
13F, latest reported quarter
REVENUE GROWTH
+20.4%
XBRL, annual
NET MARGIN
-5026.0%
SEVEN FACTS, RANKED AGAINST THE SECTOR · RANK IS NOT A FORECAST
INSIDERS
net -$77.2K over 180 days
-$30.6K over 90 days
more than 56% of Pharma & Biotech
CONGRESS
no member of Congress has reported trading it
FUNDS
103 funds added or opened last quarter
more than 66% of Pharma & Biotech
REVENUE
+20.4% year over year
more than 69% of Pharma & Biotech
MARGIN
-5026.0% net margin
below 98% of Pharma & Biotech
BUYBACKS
no share repurchases reported
SHORT
no short interest reported
THE SITUATION · EVERY LINE IS ONE RULE OVER ONE DATASET
Insiders are net sellers: -$77.2K across 5 people in 180 days.
103 funds added or opened positions in the latest 13F quarter, of 150 holders.
The year, with the filings on it
Total return indexed to 100 over the last 12 months · every marker is a federal filing, placed at its date — hover any marker for the detail
TOTAL 12M RETURN -68.0%
-68.0%12M
-71%-27%+17%+61%2025-092025-102025-122026-032026-052026-072026-09 2026-03-16 · Sutherland Everett Rand sold $19.4K2026-06-16 · Sutherland Everett Rand sold $12.8K2026-03-16 · Deykin Aaron sold $8.3K2026-03-16 · GRAY MICHAEL sold $7.9K2026-03-16 · Houghton Adam sold $6.5K2026-06-16 · Deykin Aaron sold $5.5K2026-06-16 · GRAY MICHAEL sold $5.2K2026-03-16 · Ambrose Allison sold $4.4K2026-06-16 · Houghton Adam sold $4.3K2026-06-16 · Ambrose Allison sold $2.9K
INSIDER SELL
INDEXED RETURN, DIVIDEND-ADJUSTED — NOT A PRICE CHART · LARGE TRADES DRAWN FIRST WHEN A NAME FILES HEAVILY
Live price
Daily candles from TradingView, on their licence — no filings are marked on this one
WHY THIS NAME IS ON THE DESK
The complete filing record, in one place.
The record shows a net $77.2K sold by insiders over 180 days, 103 funds added last quarter. Every figure is a federal filing, dated the day it became public.
Backtest this pattern Open the screener
Same sector, ranked by filing activity
Sector from the SEC's own SIC classification
UTHRCPIXMRNAREGNLLYALNYELFCITRMDGLDNAVRTXNUVL
Insider transactions
Form 4 purchases and sales (codes P and S) — grants, option exercises and preferred conversions excluded

Over the last 180 days, Upstream Bio, Inc. insiders sold a net $77.2K of stock across 15 Form 4 purchases and sales, with 0 insider(s) buying. Source: SEC Form 4 filings, as of 2026-09-04.

INSIDER
FILED
SHARES
VALUE
GRAY MICHAEL
CFO and COO
SELL
2026-06-16
853.0
$5.2K
Sutherland Everett Rand
Chief Executive Officer
SELL
2026-06-16
2,095.0
$12.8K
Houghton Adam
Chief Business Officer
SELL
2026-06-16
700.0
$4.3K
Deykin Aaron
Chief Medical Officer
SELL
2026-06-16
895.0
$5.5K
Ambrose Allison
General Counsel
SELL
2026-06-16
477.0
$2.9K
15 TRANSACTIONS ON RECORD

Showing the most recent few. Create a free account to see 10 more transactions on record, the cross-source screener and CSV export. We store only your email address, and there is no password to create.

Institutional holders
13F · holdings as of the latest quarter funds have reported
FMR LLC
8,162,897.0 sh
$56.5M
ORBIMED ADVISORS LLC
5,693,589.0 sh
$39.4M
NORGES BANK
3,768,619.0 sh
$26.1M
BlackRock, Inc.
3,753,358.0 sh
$26.0M
Decheng Capital LLC
2,724,868.0 sh
$18.9M
SCHEDULE 13D/G
No 5%+ ownership filings
Nobody has crossed 5% with a filing obligation. Absence is a fact here, not missing data.
FORM 144
No planned-sale notices
No insider has notified an intent to sell. This is the panel to watch after a run-up.
Fund concentration
N-PORT · funds ranked by how much of THEMSELVES they put in this stock — the conviction number 13F cannot show
Simplify Propel Opportunities ETF
$700.1K POSITION · AS OF 2026-03-31
1.0%
Fidelity Advisor Biotechnology Fund
$6.3M POSITION · AS OF 2026-04-30
0.3%
ALPS Medical Breakthroughs ETF
$369.9K POSITION · AS OF 2026-02-28
0.3%
VANGUARD MARKET NEUTRAL FUND
$1.1M POSITION · AS OF 2026-03-31
0.3%
Virtus Biotech Clinical Trials Etf
$93.4K POSITION · AS OF 2026-04-30
0.3%
Fidelity Disruptive Medicine ETF
$122.9K POSITION · AS OF 2026-02-28
0.2%
SEC N-PORT, MONTHLY WITH A ~60-DAY PUBLIC LAG · FUNDS ≥ $10M · % = SHARE OF THE FUND'S OWN BOOK
Clinical pipeline
ClinicalTrials.gov · 6 registered trials, 2 still enrolling or running — a status change here is dated weeks before the press release
2
Phase 1
0 ACTIVE
4
Phase 2
2 ACTIVE
TRIALS MATCHED TO THIS TICKER BY SPONSOR NAME · STUDIES RUN UNDER A SUBSIDIARY'S OWN NAME ARE NOT INCLUDED
Fundamentals
Annual figures from XBRL filings · pick a past date to see them exactly as the market knew them then — restatements and all
2025-122024-122023-12
REVENUE$2.9M$2.4M$2.4M
OPERATING INCOME$-160.4M$-77.8M$-40.1M
NET INCOME$-143.4M$-62.8M$-20.5M
EPS (DILUTED)-2.66-5.58-12.95
OPERATING CASH FLOW$-133.3M$-59.2M$-37.9M
CASH$101.6M$325.9M$25.8M
SEC XBRL · FISCAL-YEAR PERIODS · AS KNOWN ON 2026-09-04 · NOBODY ELSE SHOWS FUNDAMENTALS AS OF A PAST DATE
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Public filings, honestly analyzed. Official US government sources in one desk — every figure carries the date it was filed, and the methodology is published, backtest included.

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© 2026 WAVEMAN · SOURCE: SEC EDGAR & OFFICIAL GOVERNMENT DATA · NOT INVESTMENT ADVICE · CHART BY TRADINGVIEW · UPDATED 2026-09-04 ALL SYSTEMS LIVE FOR MACHINES →