Opaleye Management Inc. 13F holdings
Opaleye Management Inc. reported 58 positions with a total reported value of $1.1B as of 2026-06-30, in its 13F for Q2 2026, filed 2026-08-14. Top holdings by reported value: LQDA LIQUIDIA CORPORATION (17.7%), ETON ETON PHARMACEUTICALS INC (9.4%), HROW HARROW INC (9.2%), IRON DISC MEDICINE INC (5.7%), URGN UROGEN PHARMA LTD (4.8%). Against 2026-03-31 it opened 13 new positions and exited 8. Next 13F due by 2026-11-14, the legal deadline 45 days after the quarter ending 2026-09-30.
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Top holdings
25 largest of 58 positions · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| LQDA LIQUIDIA CORPORATION | 2,447,500 | $195.1M | 17.7% |
| ETON ETON PHARMACEUTICALS INC | 2,860,000 | $103.5M | 9.4% |
| HROW HARROW INC | 2,400,000 | $101.9M | 9.2% |
| IRON DISC MEDICINE INC | 855,000 | $62.5M | 5.7% |
| URGN UROGEN PHARMA LTD | 1,439,996 | $53.0M | 4.8% |
| APGE APOGEE THERAPEUTICS INC | 390,000 | $51.8M | 4.7% |
| MGTX MEIRAGTX HLDGS PLC | 3,550,000 | $48.0M | 4.3% |
| SLGL SOL-GEL TECHNOLOGIES LTD | 500,000 | $37.1M | 3.4% |
| RZLT REZOLUTE INC | 6,300,000 | $32.8M | 3.0% |
| TGTX TG THERAPEUTICS INC | 535,000 | $29.4M | 2.7% |
| IMMX IMMIX BIOPHARMA INC | 2,345,000 | $24.2M | 2.2% |
| CBIO CRESCENT BIOPHARMA INC. | 1,319,351 | $23.7M | 2.2% |
| STOK STOKE THERAPEUTICS INC | 700,000 | $22.9M | 2.1% |
| ACOG ALPHA COGNITION INC | 2,895,467 | $20.9M | 1.9% |
| EWTX EDGEWISE THERAPEUTICS INC | 500,000 | $20.3M | 1.8% |
| RVMD REVOLUTION MEDICINES INC | 100,000 | $18.7M | 1.7% |
| GLUE MONTE ROSA THERAPEUTICS INC | 745,000 | $18.0M | 1.6% |
| ALMS ALUMIS INC | 550,000 | $15.5M | 1.4% |
| CDXS CODEXIS INC | 6,785,000 | $15.3M | 1.4% |
| REPL REPLIMUNE GROUP INC | 1,384,993 | $15.3M | 1.4% |
| XOMA XOMA ROYALTY CORPORATION | 338,374 | $14.4M | 1.3% |
| MBX MBX BIOSCIENCES INC | 260,000 | $14.4M | 1.3% |
| RYTM RHYTHM PHARMACEUTICALS INC | 122,500 | $13.6M | 1.2% |
| EDIT EDITAS MEDICINE INC | 3,861,930 | $12.5M | 1.1% |
| PTGX PROTAGONIST THERAPEUTICS INC | 100,000 | $12.3M | 1.1% |
SEC FORM 13F · Q2 2026 · VALUES AS REPORTED, NOT PRICES
New positions this quarter
Held at 2026-06-30, not at 2026-03-31 · 13 in all · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| IMMX IMMIX BIOPHARMA INC | 2,345,000 | $24.2M | 2.2% |
| GLUE MONTE ROSA THERAPEUTICS INC | 745,000 | $18.0M | 1.6% |
| REPL REPLIMUNE GROUP INC | 1,384,993 | $15.3M | 1.4% |
| VSTM VERASTEM INC | 1,800,000 | $6.9M | 0.6% |
| PHAT PHATHOM PHARMACEUTICALS INC | 185,589 | $2.0M | 0.2% |
| INBX INHIBRX BIOSCIENCES INC | 20,291 | $1.9M | 0.2% |
| COAG HEMAB THERAPEUTICS HLDGS INC | 47,652 | $1.8M | 0.2% |
| TRAX FIRST TRACKS BIOTHERAPEUTICS | 65,000 | $1.3M | 0.1% |
| BHVN BIOHAVEN LTD | 77,915 | $1.2M | 0.1% |
| KTTA PASITHEA THERAPEUTICS CORP | 2,050,000 | $1.1M | <0.1% |
| ADCT ADC THERAPEUTICS SA | 700,000 | $749.0K | <0.1% |
| OKYO OKYO PHARMA LTD | 375,204 | $562.8K | <0.1% |
| PTN PALATIN TECHNOLOGIES INC | 20,500 | $221.2K | <0.1% |
Sold out
Held at 2026-03-31, gone by 2026-06-30 · 8 in all · reported value as of 2026-03-31
| Holding | Shares 2026-03-31 | Reported value | % of portfolio then |
|---|---|---|---|
| CATX PERSPECTIVE THERAPEUTICS INC | 4,875,000 | $20.3M | 2.7% |
| ASSERTIO HOLDINGS INC | 265,707 | $5.1M | 0.7% |
| STRO SUTRO BIOPHARMA INC | 190,671 | $4.7M | 0.6% |
| TECX TECTONIC THERAPEUTIC INC | 123,000 | $3.8M | 0.5% |
| RIGL RIGEL PHARMACEUTICALS INC | 70,000 | $1.9M | 0.2% |
| NXTC NEXTCURE INC | 141,181 | $1.5M | 0.2% |
| PLX PROTALIX BIOTHERAPEUTICS INC | 340,000 | $737.8K | <0.1% |
| LBRX LB PHARMACEUTICALS INC | 14,506 | $357.7K | <0.1% |
Biggest increases and decreases
Positions held at both quarter ends, by change in shares · reported value as of 2026-06-30
Increases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| IRON DISC MEDICINE INC | 421,000 | 855,000 | +103.1% | $62.5M |
| MGTX MEIRAGTX HLDGS PLC | 2,123,259 | 3,550,000 | +67.2% | $48.0M |
| CABA CABALETTA BIO INC | 1,380,000 | 3,863,800 | +180.0% | $12.0M |
| EDIT EDITAS MEDICINE INC | 1,926,997 | 3,861,930 | +100.4% | $12.5M |
| BBOT BRIDGEBIO ONCOLOGY THERAPEUT | 53,282 | 700,000 | +1,213.8% | $5.3M |
| LYEL LYELL IMMUNOPHARMA INC | 79,097 | 344,025 | +334.9% | $4.8M |
| FDMT 4D MOLECULAR THERAPEUTICS IN | 112,291 | 334,437 | +197.8% | $4.4M |
| ACOG ALPHA COGNITION INC | 2,561,950 | 2,895,467 | +13.0% | $20.9M |
| XOMA XOMA ROYALTY CORPORATION | 300,000 | 338,374 | +12.8% | $14.4M |
| URGN UROGEN PHARMA LTD | 1,430,000 | 1,439,996 | +0.7% | $53.0M |
| RCKT ROCKET PHARMACEUTICALS INC | 955,000 | 1,000,000 | +4.7% | $3.4M |
| VYGR VOYAGER THERAPEUTICS INC | 1,150,000 | 1,185,000 | +3.0% | $4.1M |
Decreases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| HROW HARROW INC | 2,832,230 | 2,400,000 | -15.3% | $101.9M |
| LQDA LIQUIDIA CORPORATION | 2,545,000 | 2,447,500 | -3.8% | $195.1M |
| SNWV SANUWAVE HEALTH INC | 981,267 | 306,140 | -68.8% | $3.1M |
| JBIO JADE BIOSCIENCES INC | 427,608 | 145,000 | -66.1% | $3.2M |
| CGON CG ONCOLOGY INC | 94,800 | 17,789 | -81.2% | $1.3M |
| DERM JOURNEY MED CORP | 960,000 | 350,000 | -63.5% | $2.5M |
| QTTB Q32 BIO INC | 1,256,228 | 931,000 | -25.9% | $11.9M |
| ANNX ANNEXON INC | 2,331,761 | 1,714,451 | -26.5% | $9.8M |
| BDSX BIODESIX INC | 238,047 | 180,000 | -24.4% | $4.1M |
| TRVI TREVI THERAPEUTICS INC | 345,100 | 310,000 | -10.2% | $5.8M |
| FBIO FORTRESS BIOTECH INC | 1,042,000 | 890,000 | -14.6% | $2.7M |
| AVIR ATEA PHARMACEUTICALS INC | 322,600 | 235,000 | -27.2% | $1.1M |
CIK 1595855 · 13F FILINGS ON EDGAR · INFORMATIONAL ONLY
