5AM Venture Management, LLC 13F holdings
5AM Venture Management, LLC reported 16 positions with a total reported value of $287.9M as of 2026-06-30, in its 13F for Q2 2026, filed 2026-08-14. Top holdings by reported value: MPLT MAPLIGHT THERAPEUTICS INC (11.8%), TYRA TYRA BIOSCIENCES INC (11.4%), TRDA ENTRADA THERAPEUTICS INC (10.4%), PHVS PHARVARIS N V (9.6%), CAMP CAMP4 THERAPEUTICS CORP (8.9%). Against 2026-03-31 it opened 0 new positions and exited 4. Next 13F due by 2026-11-14, the legal deadline 45 days after the quarter ending 2026-09-30.
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Top holdings
16 largest of 16 positions · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| MPLT MAPLIGHT THERAPEUTICS INC | 950,011 | $34.0M | 11.8% |
| TYRA TYRA BIOSCIENCES INC | 1,029,298 | $32.9M | 11.4% |
| TRDA ENTRADA THERAPEUTICS INC | 4,056,379 | $29.9M | 10.4% |
| PHVS PHARVARIS N V | 797,600 | $27.6M | 9.6% |
| CAMP CAMP4 THERAPEUTICS CORP | 5,869,091 | $25.6M | 8.9% |
| ARTV ARTIVA BIOTHERAPEUTICS INC | 2,353,304 | $22.8M | 7.9% |
| TECX TECTONIC THERAPEUTIC INC | 606,660 | $20.9M | 7.2% |
| ZNTL ZENTALIS PHARMACEUTICALS INC | 3,947,913 | $19.1M | 6.7% |
| CLDX CELLDEX THERAPEUTICS INC NEW | 497,270 | $18.5M | 6.4% |
| EYPT EYEPOINT INC | 1,050,000 | $15.0M | 5.2% |
| BHVN BIOHAVEN LTD | 738,972 | $11.0M | 3.8% |
| SRZN SURROZEN INC | 271,250 | $7.0M | 2.4% |
| SKYE SKYE BIOSCIENCE INC | 9,681,763 | $6.7M | 2.3% |
| ALXO ALX ONCOLOGY HLDGS INC | 3,057,325 | $6.3M | 2.2% |
| TARA PROTARA THERAPEUTICS INC | 1,369,782 | $5.2M | 1.8% |
| SLN SILENCE THERAPEUTICS PLC | 476,200 | $5.2M | 1.8% |
SEC FORM 13F · Q2 2026 · VALUES AS REPORTED, NOT PRICES
New positions this quarter
Held at 2026-06-30, not at 2026-03-31 · 0 in all · reported value as of 2026-06-30
No new positions.
Sold out
Held at 2026-03-31, gone by 2026-06-30 · 4 in all · reported value as of 2026-03-31
Biggest increases and decreases
Positions held at both quarter ends, by change in shares · reported value as of 2026-06-30
Increases
No position was increased.
Decreases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| SRZN SURROZEN INC | 387,500 | 271,250 | -30.0% | $7.0M |
CIK 1799883 · 13F FILINGS ON EDGAR · INFORMATIONAL ONLY
