ARCH Venture Management, LLC 13F holdings
ARCH Venture Management, LLC reported 12 positions with a total reported value of $1.1B as of 2026-06-30, in its 13F for Q2 2026, filed 2026-08-14. Top holdings by reported value: PBLS PARABILIS MEDICINES INC (16.0%), BEAM BEAM THERAPEUTICS INC (14.2%), RAPP RAPPORT THERAPEUTICS INC (14.1%), SPTX SEAPORT THERAPEUTICS INC (12.4%), ERAS ERASCA INC (11.8%). Against 2026-03-31 it opened 3 new positions and exited 1. Next 13F due by 2026-11-14, the legal deadline 45 days after the quarter ending 2026-09-30.
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Top holdings
12 largest of 12 positions · reported value as of 2026-06-30
| Holding | Shares | Reported value | % of portfolio |
|---|---|---|---|
| PBLS PARABILIS MEDICINES INC | 6,412,780 | $175.5M | 16.0% |
| BEAM BEAM THERAPEUTICS INC | 4,540,132 | $155.8M | 14.2% |
| RAPP RAPPORT THERAPEUTICS INC | 3,728,738 | $155.4M | 14.1% |
| SPTX SEAPORT THERAPEUTICS INC | 6,294,951 | $136.6M | 12.4% |
| ERAS ERASCA INC | 7,091,557 | $129.9M | 11.8% |
| VIR VIR BIOTECHNOLOGY INC | 12,694,163 | $129.4M | 11.8% |
| MAZE MAZE THERAPEUTICS INC | 4,120,053 | $123.0M | 11.2% |
| LYEL LYELL IMMUNOPHARMA INC | 3,247,162 | $45.5M | 4.1% |
| GENB GENERATE BIOMEDICINES INC | 1,944,426 | $32.8M | 3.0% |
| TXG 10X GENOMICS INC | 217,834 | $8.4M | 0.8% |
| BOLD BOUNDLESS BIO INC | 2,694,095 | $6.7M | 0.6% |
| GOSS GOSSAMER BIO INC | 8,055,916 | $1.3M | 0.1% |
SEC FORM 13F · Q2 2026 · VALUES AS REPORTED, NOT PRICES
New positions this quarter
Held at 2026-06-30, not at 2026-03-31 · 3 in all · reported value as of 2026-06-30
Sold out
Held at 2026-03-31, gone by 2026-06-30 · 1 in all · reported value as of 2026-03-31
| Holding | Shares 2026-03-31 | Reported value | % of portfolio then |
|---|---|---|---|
| QTTB Q32 BIO INC | 320,482 | $2.1M | 0.3% |
Biggest increases and decreases
Positions held at both quarter ends, by change in shares · reported value as of 2026-06-30
Increases
No position was increased.
Decreases
| Holding | Shares 2026-03-31 | Shares 2026-06-30 | Change | Reported value |
|---|---|---|---|---|
| VIR VIR BIOTECHNOLOGY INC | 12,916,663 | 12,694,163 | -1.7% | $129.4M |
CIK 1274403 · 13F FILINGS ON EDGAR · INFORMATIONAL ONLY
